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New Nanoparticles Could Revolutionize Therapeutic Drug Discovery
A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) which could lead to 30 per cent more proteins being available as potential targets for drug development - opening up exciting possibilities in drug discovery.
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Advocates Express Concern About Embryonic Stem Cell Research Guidelines As Comment Period Closes
Supporters of embryonic stem cell research have expressed concern about the impact on existing research efforts under the Obama administration"s draft guidelines outlining criteria for federal funding of stem cell research, the Washington Post reports. The public comment period for the guidelines ends Tuesday and has generated more than 20,000 comments addressing nearly every element of the proposal. The guidelines, which NIH issued in April, propose limiting federal funding for the research to stem cells derived from unused embryos created for fertility treatments and willingly donated by patients who have given written consent. Former President George W. Bush in August 2001 enacted restrictions limiting federal funding for the research to the 21 stem cell lines existing at the time. Although President Obama in March signed an executive order lifting Bush"s restrictions, some proponents of embryonic stem cell research have suggested that Obama"s plan could actually jeopardize many existing research efforts. The Obama administration is expected to issue its final version of the guidelines by July 7, the Post reports.After Bush restricted federal funding to the embryonic stem cell lines already in existence, many researchers turned to private donors and state governments for the financial support to create hundreds of new lines. Although supporters of the research initially were pleased that the Obama administration"s guidelines would allow federal funding for research on these new existing lines, some are now concerned that certain stipulations in the new guidelines could actually disqualify these research efforts from receiving federal funding. For example, NIH"s proposal requires that couples who wish to donate unused embryos for research sign a consent form indicating that they were fully informed of their alternatives. Although many fertility clinics provide information for couples about their other options, few clinics note these details in written consent forms, according to the Post. Therefore, existing stem cell lines derived from embryos donated by couples who did not sign the required consent forms could be ineligible under NIH"s draft proposal, the Post reports. In addition, many stem cell research supporters also expressed disappointment that only unused embryos created for fertility treatments would be eligible for federal funding.George Daley of the Harvard Stem Cell Institute said that the Obama administration"s guidelines "take 2009 standards and attempt to apply them retroactively, which isn"t really a standard that would allow most of the pre-existing lines to be acceptable for NIH funding." Lawrence Goldstein, director of the University of California-San Diego"s stem cell program, said, "It"s not that past practices were shoddy. But they don"t necessarily meet every letter of the new guidelines moving forward." Goldstein added that researchers would "have to throw everything out and start all over again" under the new proposed guidelines. Amy Comstock Rick, CEO of the Coalition for the Advancement of Medical Research, said that her group is "very concerned" about the funding prospects for existing research efforts, adding that if NIH officials do not modify the guidelines, "very little current research would be eligible" to receive federal funds. However, Raynard Kington, acting NIH director, said the agency is aware of the concerns and "will take them into consideration." He added that "it"s unambiguous that the intent of the president was to expand opportunities and research in this area," as long as such research is "scientifically worthy" and "ethically responsible" (Stein, Washington Post, 5/25).
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American Chemical Society To Publish New Journal Focusing On Neuroscience Research
With neuroscience on the threshold of unprecedented advances in understanding and treating Alzheimer"s disease, Parkinson"s disease, autism, and a range of other disorders of the brain and nervous system, the American Chemical Society (ACS) announced plans to launch a new journal devoted to the molecular basis of neurological disease.
Diagnostics

Campaign Welcome Parliamentary Report Exposing Serious Failings In Treatment For Alcohol Dependents Across England

UK Advocates (UKA), a new charitable campaign group dedicated to helping the still suffering alcoholic achieve lasting sobriety, has welcomed the All Party Parliamentary Group (APPG) on Alcohol Misuse report published which calls for urgent action to address serious shortcomings in the treatment of alcohol dependents in England. UKA was set up to lobby and hold to account health professionals and policymakers at both national and local level who are presiding over a failing system of treatment for people with chronic problems with alcohol at a time when there is widespread concern over out of control binge drinking, particularly among women and the young. Recent estimates put the proportion of the population affected directly or indirectly by alcohol addiction at 14 per cent, alcohol-related admissions to hospitals are touching the 1 million mark annually at a cost of almost £3 billion to the taxpayer and experts now believe up to 40,000 deaths are caused by alcohol abuse every year. UKA is campaigning to shift the emphasis of treatment away from short-term, often chemical-orientated interventions and controlled drinking programmes - both of which can prove dangerous to the sufferer - towards free at point of access, structured, long-term abstinence programmes. Although there is a serious lack of official figures comparing the relative effectiveness of different treatments for alcohol dependency, many experts in the field, including the World Health Organisation (WHO), consider abstinence by far the most likely means to securing lasting sobriety for those affected by alcoholism. For instance, the programme of Alcoholics Anonymous is widely accepted as the most successful of its kind and now boasts over two million members worldwide, 60,000 of them in London alone. The APPG inquiry was set up to investigate the state of alcohol treatment services in England following recent critical reports on the care of alcohol misusers by the National Audit Office and Alcohol Concern, and took evidence from practitioners, treatment providers and experts in the field of addiction. The subsequent report confirms UKA"s assertion that the current system is in a state of chaos and urgently needs radical reshaping and reform. The APPG report notes "a general lack of capacity and variety in alcohol treatment services, due to poor levels of funding and, in some cases, a harm reduction agenda driven largely by crime and disorder rather than health considerations" and points to the fact that despite 1.1 million people being classified as alcohol dependent nationally only 1 in 18 enter any sort of specialist treatment every year. Spending on illegal drug addiction still heavily outweighs that on alcohol dependency, despite the burgeoning size of the problem and figures that show that for every £1 spent on alcohol treatment, £5 is saved elsewhereÂð. The APPG report also reveals a huge discrepancy between the stated goals of the Department of Health (DoH) on the provision of alcohol treatment and how this is met, or not met, at local level by the autonomous Primary Care Trusts (PCTs) that they fund. It says: "Ò€¦the Department has been powerless to insist that local alcohol treatment is either considered or provided, even where the need has been most transparent. This lack of strategic focus has meant that alcohol treatment provision at the local level has been left largely unplanned, under-funded and undervalued." Bob Beckett, founder of UKA, said: "Government policy has failed to recognize the difference between a problem drinker and an alcoholic who has a disease. For the alcoholic it is a bit like the gherkin which can never be a cucumber again. "The consequences of this mistake are a constant flow of over one million people every year being admitted to NHS hospitals with alcohol-related diseases at a cost to the taxpayer of almost £3 billion a year. "We need a complete and urgent rethink of the whole system if we are to make any inroads into this national catastrophe." UKA is currently carrying out an audit of the treatment provided by individual PCTs across the country and assessing whether the treatment they provide clients meets the WHO"s definition of alcoholism and its proper treatment. Legal action will be taken against those it believes have been negligent by failing to offer proper care for those diagnosed with the disease. Current funding through PCTs for abstinence-based treatments, often residential, is haphazard to the say the least and often not offered at all. Many suffers are forced to pay privately, meaning thousands who cannot afford it slip through the net completely. UKA is also compiling evidence of individual alcoholics who have been put on controlled drinking regimes or prescribed powerful psycho-active medication while still drinking, often contrary to the strict guidelines laid down by the manufacturers and licensing authorities. It intends to issue proceedings in the Administrative Division of the High Court against PCT"s and clinicians who may be proven to have acted negligently. However, the picture is not universally bleak. Nottingham, which has historically been at the forefront of alcohol treatment since Beckett opened the original Nottingham Priory under private/public partnership in 1989, have recently opened a new abstinence day treatment centre with funding from the local PCT in partnership with Mimosa Healthcare and the East Midlands-based Alcohol Problems Advice Service (APAS). UKA hope that Nottingham"s example will be followed by other PCTs and treatment agencies across the country. Note - Bob Beckett, the founder of UK Advocates and a recovering alcoholic of 21 years, helped open the original Nottingham Priory in 1989 and has acted as an advisor on alcohol treatment both in the UK and the US for the past 20 years References: Âð. National Treatment Agency (2006) Review of the Effectiveness of Treatment for Alcohol Problems UK Advocates


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