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Urologist And Allergist Explore Link Between Allergies And Interstitial Cystitis
Allergy testing and treatment may offer a new therapeutic option for many patients with interstitial cystitis (IC). IC is a severely painful bladder condition affecting as many as 8 million women and 1.5 million men in the United States. Patients and the providers who treat them have long noticed a correlation between allergies and IC. Recently, a urologist and allergist in Louisville, Kentucky, began to explore the link between these two chronic ailments to provide patients with more effective treatment. The story of their discoveries is featured in the ICA Update, the quarterly magazine of the Interstitial Cystitis Association (ICA).
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Newly Published Article Details How PGS Techniques Directly Effect Successful Pregnancy Outcomes
A group of fertility experts, who pioneered the development of Preimplantation Genetic Screening (PGS), are sharing the step-by-step best practices and explaining what errors can be made along the way.
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Owners Of Ayrshire Meat Processing Plant Fined ÷£30,000 After Worker Loses Three Fingers In Machinery
The owners of a Prestwick meat processing plant have been convicted of failing to have a safe isolation procedure in place for machinery, after a worker lost three fingers when a machine he was attempting to repair started up.
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Carbon Monoxide Prevents Clotting

Researchers led by Drs. James F. George and Anupam Agarwal at the University of Alabama at Birmingham have found that carbon monoxide (CO) can protect against arterial clotting. They report their data in the July 2009 issue of the American Journal of Pathology. Carbon monoxide poisoning is extremely toxic; exposure prevents oxygen delivery to body tissues and is often fatal. However, inflamed or injured tissues upregulate heme oxygenase-1 (HO-1), a protein that both protects cells and produces CO, suggesting that low levels of CO may have protective effects. To determine if HO-1 and CO can protect against arterial clotting, Chen et al examined clotting mechanisms in mice that received arterial transplants. Absence of HO-1 in these mice resulted in significant mortality due to arterial clotting; however, treatment with a CO-releasing molecule both decreased clotting and improved survival. Drs. George, Agarwal, and colleagues conclude that HO-1/CO plays an "important role ̣€¦[in] protection against vascular arterial thrombosis in murine aortic allotransplantation." Chen B, Guo L, Fan C, Bolisetty S, Joseph R, Wright MM, Agarwal A, George JF: Carbon Monoxide Rescues Heme Oxygenase-1-deficient Mice from Arterial Thrombosis in Allogeneic Aortic Transplantation. Am J Pathol 2009, 174: 2832-2839 Angela Colmone American Journal of Pathology


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