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Connecticut Executive Order Cuts Funding To Drop-In Centers That Help People Living With HIV/AIDS
In Connecticut, representatives from several social service agencies gathered in front of the Governor"s mansion on Monday to oppose an executive order that "has cut funding to the half dozen walk-in centers around the state" that assist people living with HIV/AIDS to "zero," WTNH.com reports. Gov. Jodi Rell (R) is operating with executive orders because there is no state budget agreement. More than 10,000 state residents would be affected by the cuts, according to WTNH.com. Representatives from some of the centers said they would be forced to close without the state funding. "Simply put, there are no other agencies or funding s that can, or will, provide these services," Shawn Lang of CT AIDS Re Coalition, said (Davis, 7/6).
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Tiny Rifts Create Fragility Of Brittle Bone Disease - New Research Published In Biophysical Journal
The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon.
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Lawmakers Examining Nonprofit Hospitals' Tax Breaks
Nonprofit hospitals will lobby Congress to keep hands off their charitable status - which grants large tax exemptions, costing the government revenue - as lawmakers plan a health care overhaul, the New York Times reports. The leading senators of the Senate Finance Committee, Max Baucus, D-Mont., and Charles Grassley, R-Iowa, are considering a requirement that hospitals must provide a set amount of free care to benefit from the tax perks.
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Enzyme Modification Brings 'Corrective Genes' Closer

Scientists from the Universitçİ de Montrçİal and McGill University have re-engineered a human enzyme, a protein that accelerates chemical reactions within the human body, to become highly resistant to harmful agents such as chemotherapy, according to a new study published in The Journal of Biological Chemistry. "Our team modified and decoded an enzyme structure," says Joelle Pelletier, a professor at the Universitçİ de Montrçİal"s Department of Chemistry. "We discovered, to our surprise, that our intervention allowed the heart of the enzyme to increase its mobility. This unusual mobility caused the enzyme to resist the chemotherapy agent methotrexate - a result we never predicted and one that offers promise." The research team made its discovery as it sought ways to help correct genetic diseases. "Our goal is to improve the injection of corrective genes in people suffering from genetic diseases," say Pelletier who is also co-director of PROTEO, a Quebec-based research group on the function, structure and engineering of proteins. "This discovery will lead to promising new avenues." "We were intrigued to find the enzyme"s internal flexibility was impacted by our modifications and that this fact played such a crucial role for resistance," says Albert Berghuis, a professor at the McGill University Department of Biochemistry and Canada Research Chair in Structural Biology. "We can now harness this insight to further advance therapies for genetic diseases such as leukemia." Partners in research: This study was funded by the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada. About the study: The paper, "Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance," published in The Journal of Biological Chemistry, was authored by Jordan P. Volpato, Elena Fossati Jonathan Blanchet, Lucie Poulin, Vanessa Guerrero and Joelle N. Pelletier of the Universitçİ de Montrçİal; Brahm J. Yachnin and Albert M. Berghuis of McGill University. Sophie Langlois University of Montreal


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