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Alzheimer's Society Comment On New Data Observing The Cost Effectiveness Of Aricept (donepezil)
New research presented at the annual meeting of ISPOR suggests that prescribing Aricept on diagnosis of either mild or moderate Alzheimer"s disease would save the NHS money.
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Discovery May Revolutionize Therapy In Muscular Dystrophy And Other Skeletal Muscle Disorders
Researchers at UMDNJ-Robert Wood Johnson Medical School are a step closer to treating, and perhaps preventing, muscle damage caused by disease and aging. In their study, published in the June issue of Journal of Biological Chemistry, the scientists have linked the newly discovered protein MG53 to a pathway that repairs human muscle tissue along with the proteins caveolin-3 (Cav3) and dysferlin. Prior to this study, the underlying interactions that inhibited membrane repair in muscle tissue were unknown. Linking these proteins creates a mechanism that allows damaged membranes to be repaired, which may transform treatment for patients who suffer from severe complications of diseases such as muscular dystrophy, as well as cardiovascular disorders and conditions related to advancing age.
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Psychotherapy Of Depression Changes Biological Parameters?
A group of German investigators demonstrated that the early increase in phosphorylated CREB (pCREB) is related to treatment response and does not depend on pharmacological interventions or brain-derived neurotrophic factor (BDNF) plasma levels. For the first time, cellular biological markers could be associated with response to psychotherapy.
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Good Governance Guidance Published For Primary Care Trust Provider Committees, UK

The Appointments Commission and the Department of Health have published guidance to help Primary Care Trusts (PCTs) with their governance arrangements for Provider Committees. Provider Committees are a committee of a PCT Board, overseeing the operations of a PCT"s provider arm. The guidance published today, "Governance Arrangements to Support PCT Provider Committees", sets out core principles that should underpin the committee"s membership and make-up. Provider Committees need to be able to focus on quality, taking into account patient safety, patient experience and effective outcomes. This guidance will help to ensure that these committees are able to independently monitor, identify and mitigate risks to patients. The guidance also offers options for recruiting the independent members and outlines their roles and responsibilities. All NHS organisations need to be underpinned by robust governance arrangements that deliver independent challenge, scrutiny and accountability. This is particularly important for community services as they transform their patterns of service and organisational structures. The Department of Health is also giving more freedom to the NHS, to allow timescales to be set locally for when a PCT must choose an organisational structure under which to operate. Moving to locally-set timescales will enable the NHS to focus on driving-up quality and productivity in community services. Minister of State for Health, Mike O"Brien, said: "This guidance will support Primary Care Trusts in ensuring their local governance arrangements are fully in place and that PCT Provider Committees are well-equipped to provide both excellent management and clinical leadership and independent scrutiny and challenge." Andrea Sutcliffe, Chief Executive of the Appointments Commission, said: "We have sought to address the concerns raised by PCTs that they needed clear guidance that was sufficiently flexible to respond to local circumstances. This guidance will help to ensure that recruitment of independent members to Provider Committees is supported by a process that is fair, rigorous, transparent and that is able to stand up to public scrutiny." Jonathan Montgomery, Chair of Hampshire PCT, said: ""I welcome the publication of today"s guidance, which contains principled and practical advice on how to ensure robust governance arrangements are in place for PCT provided services. It promotes consistency of practice and conformity with the high standards governance that patients and the public expect of NHS organisations, while recognising that the precise form of arrangements depends on local circumstances. "It also contains important advice on the recruitment of independent members to Provider Committees, to provide the challenge and scrutiny necessary to give assurance that provider services are strategically led and that risks are effectively managed." The guidance is available to download from the Appointments Commission"s website http://www.appointments.org.uk/providergovernance. A Frequently Asked Questions section to update PCTs on key issues and developments is also available on this site. Department of Health, UK


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