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IRIN Examines 'Dramatic Plunge' In Family Planning International Donor Funding
IRIN examines how a "dramatic plunge" in international donor funding for family planning could undermine other health- and humanitarian-related goals, including fighting poverty and hunger. About 200 million women do not have access to contraception, which could cause a surge in the world"s population leading to a reversal of humanitarian gains, according to some experts.
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In Pregnancy, Summer Heat Increases Risk Of Amniotic Fluid Level Deficiency, Ben-Gurion University Study Reveals
Pregnant women have a higher incidence of insufficient amniotic fluid levels (oligohydramnios) in the summer months due to dehydration, according to a study conducted by researchers at Ben-Gurion University of the Negev (BGU).
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Phase III Trial Shows Addition Of A New Agent Causes Big Reduction In Nausea And Vomiting After Chemotherapy
Chemotherapy-induced nausea and vomiting (CINV) remains a clinical management problem after treatment with highly emetogenic chemotherapy (HEC)*. A study has shown that the addition of a third drug (casopitant mesylate/CM) to a conventional two-drug regimen (dexamethasone and ondansetron) causes a big reduction in CINV events. The findings are reported in an Article published Online First and in the June edition of The Lancet Oncology, written by Professor Steven Grunberg, University of Vermont, Burlington, VT, USA, and colleagues.
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Ligand Initiates Clinical Trial With The Selective Androgen Receptor Modulator LGD-4033, A Potential Treatment Of Muscle And Bone Disorders

Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) announced the initiation of a Phase I clinical trial with LGD-4033, a next-generation selective androgen receptor modulator (SARM) designed to provide the benefits of androgen receptor stimulation on skeletal muscle and bone without the side effects of currently marketed androgens. The Phase I study will evaluate the safety, tolerability and pharmacokinetic profile of orally administered LGD-4033. In preclinical studies, LGD-4033 demonstrated a highly tissue-selective profile with increased skeletal muscle mass and bone mineral density while largely sparing the prostate in males and masculinizing effects in females. Extensive preclinical studies with LGD-4033 demonstrate the following: - LGD-4033 is highly selective for the androgen receptor. - Gene transcriptional regulation assays using muscle or bone cells demonstrate that LGD-4033 is a potent, full agonist producing efficacy comparable to the natural steroidal androgen dihydrotestosterone. - In repeat oral dosing studies LGD-4033 increases skeletal muscle mass. - In the ovariectomized rat model of post-menopausal osteoporosis, LGD-4033 had anabolic activity in cortical bone, significantly increasing cortical bone formation rates, bone strength and bone density. LGD-4033 also suppressed bone turnover at cancellous bone sites, leading to an increase in lumbar spine bone density and strength. - In repeat oral dosing studies, LGD-4033 is a weak partial agonist on the prostate gland with more than 500-fold selectivity for muscle versus prostate. This indicates an absence of the prostatic hypertrophy that occurs with the currently marked androgens. "LGD-4033 has shown an excellent SARM profile to date in terms of efficacy, potency and selectivity, and it is potentially a novel therapeutic for muscle and bone-related disorders such as cachexia and frailty," said John L. Higgins, President and Chief Executive Officer of Ligand Pharmaceuticals. "This program is another example of how the success of Ligand"s research platform, which so far includes five approved drugs, allows us to continue investing in and strengthening a portfolio of promising candidates to address major clinical needs and commercial market opportunities." SARM Program SARMs are designed to elicit the desired biological effects without the undesirable side effects or potential risks over time of currently marketed androgens, providing a wide range of opportunities for the treatment of many diseases and disorders in both men and women. Tissue-selective androgen receptor agonists may provide utility in the treatment of a number of medical conditions, including frailty, cachexia, osteoporosis, sexual dysfunction and hypogonadism. Ligand has discovered orally active, non-steroidal SARM compounds, such as LGD-4033 and LGD-3303, based on tissue-specific gene expression and other functional, cell-based technologies. Ligand Pharmaceuticals


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