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Human Cells Evolved To Reduce Cancer Risk
The cells of humans and other animals have likely evolved to reduce the chance of triggering cancers and other diseases, according to research published in the journal Science.
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UAW To Accept Up To 20% Of GM Stock; Agrees To Concessions On Retiree Health Care Obligations, Labor Rules
United Auto Workers leaders on Tuesday agreed to accept up to 20% of General Motors stock, as well as concessions on labor rules and retiree health care obligations, as the automaker faces a June 1 deadline to restructure or seek bankruptcy protection, the Detroit News reports (Aguilar/Shepardson, Detroit News, 5/27). Under the deal, the voluntary employees" beneficiary association would receive 17.5% of common GM stock, $6.5 billion of preferred shares, a $2.5 billion note and warrants equal to 2.5% of GM"s stock (Reuters/USA Today, 5/27). In addition, the VEBA would receive $585 million annually in interest income on its preferred stock (Detroit News, 5/27). Another concession included in the tentative deal is the elimination of dental, vision and some prescription drug coverage for hourly retirees (Shepardson/Aguilar, Detroit News, 5/26). UAW also would hold a seat on the GM board of directors (Cho et al., Washington Post, 5/27).Because of a proposed deal announced earlier this month, the Treasury Department and UAW, together, are to own 89% of GM"s stock, meaning that if the UAW-GM deal is approved, the Treasury would own about a 70% share of GM"s stock (Detroit News, 5/26). Current bondholders would hold about a 10% stake in the company (Washington Post, 5/27). The remaining 1% would be held by existing shareholders (Detroit News, 5/26).The total 20% is about half of what was anticipated (Higgins, Detroit Free Press, 5/26). The "significant concessions" made by UAW, which was eligible to receive up to 39% of GM"s equity through the VEBA, "could mean that [GM] is attempting to appease unsecured bondholders, who charged that the UAW was getting a better deal," according to the News (Detroit News, 5/27). UAW said the revised agreement with GM was necessary for the automaker to survive, but the deal will leave hundreds of thousands of GM retirees paying higher out-of-pocket medical expenses, the Wall Street Journal reports (Stoll et al., Wall Street Journal, 5/27).UAW members are scheduled to vote on the agreement on Wednesday and Thursday (Detroit News, 5/26). However, "[e]ven with UAW approval, GM is still likely to file for bankruptcy, since bondholders are unlikely to swallow deep concessions," according to the News (Detroit News, 5/27).
News of the day
School Nutrition Association Recognizes Lee's Summit Child Nutrition Department As The Outstanding School Nutrition Program For 2009
Lee"s Summit School District was named the 2009 District of the Year in School Nutrition today during the 3rd General Session of the School Nutrition Association"s Annual National Conference. The District"s Child Nutrition Department was recognized for improving the health and nutrition of the district"s food offerings, implementing a strong professional development program and exercising superior financial management. Child Nutrition Director Jane Hentzler, RD, SNS accepted the award on behalf of the school district.
Oncology

Prostate Cancer - Positive Phase IIb Study For Orazol™ Tablet Form Of Zoledronate IV Infusion

Weekly tablet delivers major new benefits for patients, doctors and payors: avoiding the need for burdensome and costly infusions and related infection risks; weekly tablet dosing offers potential for better safety and side effect profile of a "gold standard" oncology drug. "The economic and treatment benefits of Orazol™ will be felt widely in the clinician and patient communities," says Merrion Pharmaceuticals CEO, John Lynch. "No longer will costly, rigid and potentially unhealthy infusions dictate treatment decisions but instead Orazol™ opens the potential for doctors to treat more patients, more efficiently while limiting adverse impact on the patients" quality of life." NEW YORK, New York, June 10, 2009 - Merrion Pharmaceuticals plc (IEX: MERR), an international specialty pharmaceutical development company, today announced very positive results from a multi centre Phase II study on Merrion"s Orazol™ drug (MER 101). The study, conducted in hormone refractory prostate cancer patients with proven bone metastases, enrolled patients at 13 sites in the US and Europe. Today"s announcement, also including the publication of comprehensive results, was made at the annual general meeting of the American Society of Clinical Oncology (ASCO). The published data shows a rapid response to treatment on biomarkers of bone resorption, in each of the study arms. These effects were noted at seven days and were sustained throughout the study period. The preliminary results show that weekly therapy with 20mg Orazol (tablet) appears to be as therapeutically effective as monthly treatment with the intravenous drug Zometa®(4mg), based on movements in observed levels of critical bone biomarkers. This was the primary endpoint of the study. Changes in bone biomarkers (e.g. NTX) have been correlated with improvement in major clinical outcomes such as Skeletal Related Events (such as bone fractures) and death. This study examined the effects of treatment on four separate bone biomarkers: urinary NTX, serum CTX, serum bone specific alkaline phosphatase and serum calcium. Orazol is a once weekly tablet form of Zoledronate, which is currently only available as an intravenous infusion. Zoledronate is a very potent and thoroughly investigated bisphosphonate compound, which has been used to treat over three million patients worldwide. Orazol, as a weekly tablet formulation, offers many new potential advantages to patients, physicians and healthcare providers. Commenting on the test results, John Lynch, Chief Executive Officer, Merrion Pharmaceuticals noted, "We are very pleased with these results. It is clear that Orazol has the potential to make an impact on patient care in the years ahead - and we will now work on identifying a licensing partner to complete Phase III development and market the product." Indeed the market opportunity for Orazol is currently substantial and also presents compelling potential for major growth. Sales of Zoledronate (Zometa® and other trademarks, Novartis).in 2008 were $1.65 billion and grew substantially over the prior year. Zoledronate is also used in osteoporosis and Paget"s disease, both of which put patients at risk of bone breakages. These areas are not currently being pursued by Merrion Pharmaceuticals, but could be once the company licenses Orazol to a partner. Orazol is made possible by Merrion Pharmaceutical"s GIPET® technology, which enables the company to make tablet forms of drugs that otherwise have to be given by injection, like Zoledronate. Several other new products are in development both by Merrion, and in collaboration with partners such as Novo Nordisk for oral insulin and GLP-1. GIPET"s unique approach allows drugs that currently can only be given parenterally to be converted into oral forms, as well as improving the absorption of current oral drugs. GIPET uses specifically designed oral formulations of patented absorption enhancers which activate facilitate transport of the drug and substantially increasing absorption with good reproducibility and a strong safety proଁle. GIPET uses Generally Regarded As Safe (GRAS) rated ingredients, permitting the development of new low-risk oral products, which can be brought rapidly and inexpensively to market to address major unmet clinical and patient needs. "Merrion Pharmaceuticals is dedicated to the premise that a wide range of injectable treatments, including many biopharmaceuticals, currently cumbersome and expensive and featuring less than satisfactory side effect profiles, may be administered orally as tablets or capsules using our patented GIPET drug delivery technology," Lynch continued. "We look forward to working closely with licensing partners to bring these treatments to the patient community and in doing so, I am convinced we"ll improve the health and quality of life for a larger, more diverse section of the world population." Written by Juliana Wynohradnyk Griffin Integrated Communications Merrion Pharmaceuticals


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