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Wiley-Blackwell Makes Research Publications On Influenza A (H1N1) Freely Available
Wiley-Blackwell, the scientific, technical, medical and scholarly publishing business of John Wiley & Sons, Inc., has launched an online reference website offering free access to top quality research articles and publications relating to Influenza A H1N1. The complimentary content includes articles from the Cochrane Library, The Hospitalist, and From Influenza and Other Respiratory Viruses, among other books and journals.
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Merck's Gardasil Effective At Preventing HPV, Cervical Disease In Older Women, Study Finds
Merck"s human papillomavirus vaccine, Gardasil, was 90% effective in preventing infection with the virus and cervical disease in women ages 24 to 45, according to a study published Monday in the medical journal Lancet, Reuters reports (Fox, Reuters, 6/1). In the U.S., the vaccine currently is FDA-approved for girls and women ages nine to 26. Centers for Disease Control and Prevention guidelines recommend routine three-dose vaccination of girls ages 11 and 12 and for girls and women ages 13 to 26 who have not yet been vaccinated (CDC fact sheet, June 2008). It is designed to protect against HPV types 16 and 18, which cause about 70% of all cervical cancer cases, and HPV types 6 and 11, which cause genital warts.The new study, led by Nubia Munoz of the National Institute of Cancer in Bogota, Colombia, and funded by Merck, involved women ages 24 to 45 with no history of cervical disease or genital warts who either received the vaccine or a placebo injection. The study found that women who received the vaccine were significantly less likely to be infected with certain strains of HPV than those who received placebo shots. According to the researchers, four women out of 1,900 who received the vaccine developed HPV or cervical disease after two years, compared with 41 women out of 1,900 in the placebo group.Reuters reports that the results of the study could help Merck as it seeks approval for marketing Gardasil for use in older women. The researchers said in the study that older women might be at risk for HPV infection as "[c]hanges in sexual behavior during the past 30 years ... have led to more widespread premarital sexual intercourse and acquisition of new sexual partners around middle age." They added, "As the potential for HPV infection and disease exists in women in their third, fourth and fifth decades of life, these women could benefit from prophylactic HPV vaccination." According to Reuters, a mathematical model published in October 2005 showed that vaccinating older women could cut rates of cervical cancer in women through age 45 by half. Merck also has released data showing the effectiveness of the vaccine in preventing genital lesions in men.According to the Centers for Disease Control and Prevention, HPV is the most common sexually transmitted infection worldwide, and about 20 million U.S. residents are infected with it. The virus is the leading cause of cervical cancer, which causes about 3,870 deaths in the U.S. and 300,000 deaths globally every year, and it also can cause anal, penile, mouth and neck cancer (Reuters, 6/1).
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Randomized Controlled Trial Shows Circumcision Does Not Reduce Male-To-Female HIV Transmission
Male circumcision does not reduce the transmission of HIV from men to their female partners, according to a Lancet study conducted in Uganda, Bloomberg reports (Sargent, 7/16). The researchers recruited 922 uncircumcised HIV-positive men between the ages of 15 and 49 for the study, who were then divided into two groups - those who were "immediately circumcised" and those for whom the procedure was "delayed for two years" Reuters reports. Researchers also followed the wives and female sex partners of the men, who all were HIV-negative (Fox, 7/16). The analysis found that "18 percent of the female partners of the circumcised men became infected with the virus compared with 12 percent of the partners of men who hadn"t undergone the procedure," Bloomberg writes (7/16). Despite studies that "suggested circumcision ò€¦ can lower the rate of male-to-female virus transmission from HIV-positive men" the researchers concluded that "[c]ircumcision of HIV-infected men didn"t reduce HIV transmission to female partners over 24 months; longer-term effects could not be assessed" (Wawer et al., Lancet, July 2009).
Diagnostics

The Journal "Foot & Ankle Specialist" Accepted In Medline

Foot & Ankle Specialist (FAS), published by SAGE, has been accepted for inclusion in MEDLINE, the premier bibliographic database of the U.S. National Library of Medicine (NLM), containing more than 16 million journal article citations. "FAS is privileged to be among the high-quality journals accepted into MEDLINE," said co-editor Gregory C. Berlet, MD. "Researchers and clinicians concerned with foot and ankle care will now be better able to access and disseminate the techniques and advancements published in the journal." Foot & Ankle Specialist is a peer-reviewed bimonthly journal offering clinical information for foot and ankle caregivers. Written and edited by orthopaedic surgeons and podiatrists, FAS offers the latest techniques and advancements in foot and ankle treatment through research reports and reviews, technical perspectives, case studies, and other evidence-based articles. FAS enables practitioners to address a broad range of disorders and provide their patients with the best current diagnosis and therapy. "SAGE is very pleased to see the important work published in FAS now included in this prestigious database," said Ron Epstein, SAGE Director, STM Journals. "It is a testament to the quality of the work and dedication of the editors Gregory C. Berlet and Babak Baravarian and the entire editorial team." Jim Gilden SAGE Publications


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