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Patients With Rheumatoid Arthritis Who Had Poor Response To Other Drugs Could Have Better Results With Golimumab
An article published Online First and in this week"s edition of reports information about Golimumab, a new tumour necrosis factor-í± (TNF-í±) inhibitor. It reduces the signs and symptoms of rheumatoid arthritis in patients who have previously received any other TNF-í± inhibitor. This drug might be a good alternative for patients who have inadequate responses to one or two other TNF-í± inhibitors.
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Next Year's Rising Health Costs May Not Be Slowed By Reform
"Employers who offer health insurance coverage could see a 9 percent cost increase next year, and their workers may face an even bigger hit, according to a report Thursday from consulting firm PricewaterhouseCoopers," the Associated Press reports. Workers concerned about losing their jobs" and their insurance, while it lasts - are using more health care than usual, contributing to rising costs, the report says. As the costs increase, employers are also likely to shift more of the burden to employees. "A total of 42% of employers surveyed said they would increase employees" share of costs," the AP reports.
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First Free Heart Testing Tour Of England
A new national campaign aiming to reduce the number of undiagnosed heart conditions will visit 12 destinations in England throughout May and June. The CRY Philips Test My Heart Tour 09 is the first free tour of its kind in England and has been made possible by charity CRY, health and well-being company Philips, through the fundraising efforts of families whose lives have been affected by Sudden Death Syndrome (SDS) or Sudden Cardiac Death (SCD), and the Gwyneth Forrester Trust. The tour aims to test over 3,000 14-35 year olds hearts to identify heart conditions which could potentially prove fatal if left untreated. To book a free appointment at one of the 12 tour locations simply go to http://www.testmyheart.org
Medical Devices

The Mystery Of Why HIV Patients Are More Susceptible To TB Infection Solved By Harvard Scientists

A team of Harvard scientists has taken an important first step toward the development of new treatments to help people with HIV battle Mycobacterium tuberculosis (TB) infection. In their report, appearing in the July 2009 print issue of the Journal of Leukocyte Biology they describe how HIV interferes with the cellular and molecular mechanisms used by the lungs to fight TB infection. This information is crucial for researchers developing treatments to help people with HIV prevent or recover from TB infection. "HIV/TB co-infection is a critical global health problem, especially in developing countries," said Naimish Patel, M.D., lead researcher on the study and Instructor of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School. "We hope that these findings will lead to further studies and possible new therapies for treating or preventing tuberculosis in HIV disease." Patel and colleagues made their discovery by extracting immune cells called "alveolar macrophages" from the lungs of otherwise healthy, asymptomatic HIV-positive patients as well as from people who did not have HIV. In people who are HIV-positive, the macrophages have a decreased response to the TB bacterium when compared to people who did not have HIV. To learn why, the scientists examined lung specimens from the HIV-positive patients and found increased levels of a molecule called IL-10, which elevated the amount of a protein called "BCL-3" in alveolar macrophages and that reduced their ability to ward off TB infection. "HIV and TB represent two of the most significant health challenges in human history and the combination of the two infections is particularly devastating because HIV dramatically increases the severity of TB infection," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "There are still many unknowns about how HIV reduces the ability of the body to combat other infections. This study sheds light on co-infection with HIV and TB, which up to this point, has perplexed scientists and physicians alike." Cody Mooneyhan Federation of American Societies for Experimental Biology


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